Ned H. Kalin
Dr. Kalin is among the most accomplished biological psychiatrists in the field. His research combines molecular, preclinical animal models, and human functional imaging studies to elucidate the mechanisms underlying the pathophysiology of anxiety and affective disorders. His work focuses on using translational models in nonhuman primates to elucidate early life mechanisms underlying the development of anxiety and depression. This work combines selective lesion strategies with functional brain imaging to demonstrate the importance of amygdala, bed nucleus of the stira terminalis, and the orbitofrontal cortex in mediating maladaptive responses to stress. Using the nonhuman primate, he has also established early markers of the risk to develop psychopathology, which has proved to be relevant to understanding risk in children. Recent studies in primates demonstrate the molecular underpinnings within the central nucleus of the amygdala that underlie early risk. Specifically, mRNA studies demonstrate alterations in the expression of neuroplasticity systems in young primates with high levels of dispositional anxiety. In rodent models, he has pursued the mechanism identified in nonhuman primates, and in humans he has performed imaging studies related to understanding mechanisms underlying emotion regulation. He is currently translating findings from his nonhuman primate studies to young children by examining alterations in brain regions underlying emotion regulation in children with high levels of anxious temperament. Taken together, his studies underscore the brain mechanisms underlying adaptive and maladaptive emotion regulation and the importance of emotion regulation in understanding individual differences related to risk for the development of stress-related psychopathology.
Professional Education
- Medical School: 1976-1979, Jefferson Medical College, Philadelphia, PA
- Residency: 1979-1981, Department of Psychiatry, University of Wisconsin School of Medicine and Public Health
- Fellow: 1981-1983, Neuropsychopharmacology, National Institute of Mental Health
Affiliations:
- Professor, Department of Psychology, University of Wisconsin Madison
- Director, HealthEmotions Research Institute, University of Wisconsin School of Medicine and Public Health
- Director, Lane Neuroimaging Laboratory, University of Wisconsin School of Medicine and Public Health
- Affiliate Scientist, Wisconsin National Primate Center and Harlow Primate Laboratory, University of Wisconsin Madison
Major National Leadership Positions (past 5 years)
- 2019 Editor in Chief, American Journal of Psychiatry
- 2017 Editorial Board, Journal of Psychiatric Research
- 2017 Member, Board of Trustees Work Group to Review the APA Relationship to Additional Funders, American Psychiatric Association
- 2016, Editorial Board, Personalized Medicine in Psychiatry
- 2016, Editorial Board, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
- 2015, Distinguished Fellow of the American Psychiatric Association
- 2015, Member, National Academy of Medicine (formerly known as Institute of Medicine)
- 2015, Board of Scientific Advisors, Pritzker Neuropsychiatric Disorders Research Consortium
- 2015-2018, Council on Research, American Psychiatric Association
- 2015, Anna-Monika Prize, Anna-Monika Foundation, European College of Neuropsychopharmacology
- 2014-2015 President, Society of Biological Psychiatry
- 2013, Fellow, American Association for the Advancement of Science
Research Activities- Current Funding
- Principal Investigator: A translational approach for identifying factors and mechanisms underlying pathological anxiety in preadolescent girls. R01MH132671, National Institute of Mental Health, $3,836,628 (6/21/23 – 4/30/28)
- Principal Investigator: Brain Mechanisms Mediating Genetic Risk for Anxiety and Depression. R01MH081884, National Institute of Mental Health, $3,873,084 (6/15/23 – 4/30/28)
- Principal Investigator: Development and Regulation of Emotion in Primates. R01MH046729, National Institute of Mental Health, $3,754,111 (4/1/22 – 3/31/27)
- Principal Investigator: Studies to understand the pathophysiology of childhood anxiety disorders, U01MH112913, National Institute of Mental Health, $3,420,084 (9/1/18 – 5/31/24)