General overview

The Kalin Lab combines molecular, preclinical animal models, and human functional imaging studies to understand the neurobiological mechanisms underlying anxiety and mood disorders.

See below for recent publications (past 3 years) and selected past publications:

Recent Publications:


Oler J.A., Tromp D.P., Fox A.S., Kovner R., Davidson R.J., Alexander A.L., McFarlin D.R., Birn R.M., E Berg B., deCampo D.M., Kalin N.H., and Fudge J.L. Connectivity between the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the non-human primate: neuronal tract tracing and developmental neuroimaging studies. Brain Structure and Function. Feb; 2016. pdf


Kalin N.H., Fox A.S., Kovner R., Riedel M.K., Fekete E.M., Roseboom P.H., Tromp D.P., Grabow B.P., Olsen M.E., Brodsky E.K., McFarlin D.R., Alexander A.L., Emborg M.E., Block W.F., Fudge J.L., and Oler J.A. Overexpressing corticotropin-releasing hormone in the primate amygdala increases anxious temperament and alters its neural circuit. Biological Psychiatry. Jan; 2016. pdf



Fox, A.S., Oler., Shackman, AJ., Shelton, SE., Raveendran, M., McKay, R., Converse, AK., Alexander, AL., Davidson, RJ., Blangero, J., Rogers, J., Kalin, N.H. Intergenerational neural mediators of early-life anxious temperament. Proceedings of the National Academy of Sciences. Jul 21:9118-22, 2015. pdf


Fox, A.S., Oler, J.A., Tromp, D.P., Fudge, J.L., and Kalin, N.H. Extending the amygdala in theories of threat processing. Trends Neuroscience. May;38(5):319-329, 2015. pdf


Kennis, M., van Rooij, S.J., Tromp, D.P., Fox, A.S., Rademaker, A.R., Kahn, R.S., Kalin, N.H. and Geuze, E. Treatment Outcome Related White Matter Differences in Veterans with Posttraumatic Stress Disorder. Neuropsychopharmacology. Sep:2434-42, 2015. pdf


Williams LE, Oler JA, Fox AS, McFarlin DR, Rogers GM, Jesson MAL, Davidson RJ, Pine DS, Kalin N.H. Fear of the unknown: Uncertain anticipation reveals amygdala alterations in childhood anxiety disorders. Neuropsychopharmacology. May:1428-35, 2015. pdf


Motzkin JC, Philippi C, Oler J, Kalin N, Baskaya M, Koenigs M. Ventromedial prefrontal cortex damage alters resting blood flow to the bed nucleus of stria terminalis. Cortex. Mar;64:281-8, 2015. pdf


Caldwell JZ, Essex MJ, Armstrong JM, Hanson JL, Sutterer MJ, Stodola DE, Koenigs M, Kalin NH, Davidson RJ. Preschool Externalizing Behavior Predicts Gender-Specific Variation In Adolescent Amygdala And Hippocampus Volumes. PLoS One. Feb 6 2015. pdf


Alisch R, Chopra P, Fox AS, Chen K, White A, Roseboom P, Keles S, Kalin NH. Differentially methylated plasticity genes in the amygdala of young primates are linked to anxious temperament, an at risk phenotype for anxiety and depressive disorders. Journal of Neuroscience. Nov 19;34(47):15548-56, 2014. pdf


Fox, A.S. and Kalin, N.H. A Translational Neuroscience Approach to Understanding the Development of Social Anxiety Disorder and Its Pathophysiology. American Journal of Psychiatry. 171, 1162-1173, 2014. pdf


Ruttle PL, Klein MH, Slattery MJ, Kalin NH, Armstrong JM, Essex MJ. Adolescent adrenocortical activity and adiposity: Differences by sex and exposure to early maternal depression. Psychoneuroendocrinology. 47:68-77, 2014. pdf


Birn, RM, Shackman, AJ, Oler, JA, Williams, LE, McFarlin, DR, Rogers, GM, Shelton, SE, Alexander, AL, Pine, DS, Slattery, MJ, Davidson, RJ, Fox, AS. Kalin, NH. Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety. Molecular Psychiatry. Aug;19(8):853, 2014. pdf


Roseboom, PH, Nanda, SA, Fox, AS, Oler, JA, Shackman, AJ, Shelton, SE, Davidson, RJ, Kalin, NH. Neuropeptide Y Receptor Gene Expression in the Primate Amygdala Predicts Anxious Temperament and Brain Metabolism. Biological Psychiatry. 76, 850-7, 2013. pdf


Heller AS, Johnstone T, Peterson MJ, Kolden GG, Kalin NH, Davidson RJ (2013). Increases in prefrontal cortex activity when regulating negative emotion predicts symptom severity trajectory over six months in depression. JAMA Psychiatry. Nov:70 (11):1181-9, 2013. pdf


Heller AS, Johnstone T, Light SN, Peterson MJ, Kolden GG, Kalin NH, Davidson RJ. Relationships between changes in sustained fronto-striatal connectivity and positive affect in major depression resulting from antidepressant treatment. American Journal of Psychiatry. Feb 1;170(2):197-206, 2013. pdf


Shackman AJ, Fox AS, Oler JA, Shelton SE, Davidson RJ, Kalin NH. Neural mechanisms underlying heterogeneity in the presentation of anxious temperament. Proceedings of the National Academy of Sciences. 110(15):6145-50, 2013. pdf


Christian BT, Wooten DW, Hillmer AT, Tudorascu DL, Converse AK, Moore CF, Ahlers EO, Barnhart TE, Kalin NH, Barr CS, Schneider ML. Serotonin transporter genotype affects serotonin 5-HT1A binding in primates. Journal of Neuroscience. 33(6):2512-6, 2013. pdf


Rosenkranz MA, Davidson RJ, Maccoon DG, Sheridan JF, Kalin NH, Lutz A. A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation. Brain, Behavior, and Immunity. 27(1):174-84, 2013. pdf


Rogers J, Raveendran M, Fawcett GL, Fox AS, Shelton SE, Oler JA, Cheverud J, Muzny DM, Gibbs RA, Davidson RJ, Kalin NH. CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression. Molecular Psychiatry. 18(6):700-707, 2013. pdf

Selected Past Publications:

Oler JA, Birn RM, Patriat R, Fox AS, Shelton SE, Burgy CA, Stodola DE, Essex MJ, Davidson RJ, Kalin NH. Evidence for coordinated functional activity within the extended amygdala of nonhuman and human primates. Neuroimage, 61(4): 1059-1066, 2012. pdf


Fox AS, Oler JA, Shelton SE, Nanda SA, Davidson RJ, Roseboom PH, Kalin NH. Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates. Proceedings of the National Academy of Sciences, 09(44):18108-13, 2012. pdf


Essex MJ, Klein MH, Slattery MJ, Goldsmith HH, Kalin NH. Early risk factors and developmental pathways to chronic inhibition and social anxiety disorder in adolescence. Am J Psychiatry. 2010 Jan; 167(1):40-6. pdf


Oler JA, Fox AS, Shleton SE, Rogers J, Dyer TD, Davidson RJ, Shelledy W, Oakes TR, Blangero J, Kalin NH. Amygdalar and hippocampal substrates of anxious temperament differ in their heritability. Nature. 2010 Aug 12; 466(7308):864-8. pdf