Recent Publications

The Kalin Lab combines molecular, preclinical animal models, and human functional imaging studies to understand the neurobiological mechanisms underlying anxiety and mood disorders.

2020

  • Kovner R, Souaiaia T, Fox AS, French DA, Goss CE, Roseboom PH, Oler JA, Riedel MK, Fekete EM, Fudge JL, Knowles JA, Kalin NH. Transcriptional Profiling of Primate Central Nucleus of the Amygdala Neurons to Understand the Molecular Underpinnings of Early-Life Anxious Temperament. Biol Psychiatry. 2020 May 19:S0006-3223(20)31595-X. doi: 10.1016/j.biopsych.2020.05.009. Online ahead of print. PMID: 32709417. pdf 
 

2019

  • Kovner R, Oler JA, Kalin NH. Cortico-Limbic Interactions Mediate Adaptive and Maladaptive Responses Relevant to Psychopathology. Am J Psychiatry. 2019 Dec 1;176(12):987-999. doi: 10.1176/appi.ajp.2019.19101064. PMID: 31787014 Free PMC article. Review. pdf
  • Tromp DPM, Fox AS, Oler JA, Alexander AL, Kalin NH. The Relationship Between the Uncinate Fasciculus and Anxious Temperament Is Evolutionarily Conserved and Sexually Dimorphic. Biol Psychiatry. 2019 Dec 15;86(12):890-898. doi: 10.1016/j.biopsych.2019.07.022. Epub 2019 Jul 31. PMID: 31542153 pdf
  • Fox AS, Souaiaia T, Oler JA, Kovner R, Kim JMH, Nguyen J, French DA, Riedel MK, Fekete EM, Rabska MR, Olsen ME, Brodsky EK, Alexander AL, Block WF, Roseboom PH, Knowles JA, Kalin NH. Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates. Biol Psychiatry. 2019 Dec 15;86(12):881-889. doi: 10.1016/j.biopsych.2019.06.022. Epub 2019 Jul 2. PMID: 31422797 pdf
  • Galvan A, Raper J, Hu X, Paré JF, Bonaventura J, Richie CT, Michaelides M, Mueller SAL, Roseboom PH, Oler JA, Kalin NH, Hall RA, Smith Y. Ultrastructural localization of DREADDs in monkeys. Eur J Neurosci. 2019 Sep;50(5):2801-2813. doi: 10.1111/ejn.14429. Epub 2019 Jun 19. PMID: 31063250 pdf
  • Kenwood MM, Roseboom PH, Oler JA, Kalin NH. New Insights Into the Mechanisms of Ketamine’s Antidepressant Effects: Understanding the Role of VEGF in Mediating Plasticity Processes. Am J Psychiatry. 2019 May 1;176(5):333-335. doi: 10.1176/appi.ajp.2019.19030282.PMID: 31039637 No abstract available.pdf
  • Kovner R, Fox AS, French DA, Roseboom PH, Oler JA, Fudge JL, Kalin NH. Somatostatin Gene and Protein Expression in the Non-human Primate Central Extended Amygdala:  Journal of Neuroscience.2018.12.035. 157-168. pdf
  • Tromp DPM, Williams LE, Fox AS, Oler JA, Roseboom PH, Rogers GM, Benson BE, Alexander AL, Pine DS, Kalin NH. Altered Uncinate Fasciculus Microstructure in Childhood Anxiety Disorders in Boys But Not Girls. Am J Psychiatry. 2019 Jan 18:appiajp201818040425. pdf

 

2018

  • Widge AS, Bilge MT, Montana R, Chang W, Rodriguez CI, Deckersbach T, Carpenter LL, Kalin NH, Nemeroff CB. Electroencephalographic Biomarkers for Treatment Response Prediction in major Depressive Illness: A Meta-Analysis. Am J Psychiatry. 2018 Oct 3: appiajp201817121358.pdf
  • Dean DC, Planalp EM, Wooten W, et al. Association of Prenatal Maternal Depression and Anxiety Symptoms With Infant White Matter Microstructure. JAMA Pediatrics. 2018 Oct 1;172(10):973-981. pdf
  • Zeier Z, Carpenter LL, Kalin NH, Rodriguez CI, McDonald WM, Widge AS, Nemeroff CB.Clinical Implementation of Pharmacogenetic Decision Support Tools for Antidepressant Drug Prescribing. The American Journal of Psychiatry. 2018 Sep 1;175(9):873-886. pdf
  • Fox AS, Oler JA, Birn RM, Shackman AJ, Alexander AL, and Kalin NH. Functional Connectivity within the Primate Extended Amygdala Is Heritable and Associated with Early-Life Anxious Temperament. Journal of Neuroscience. 2018 Aug 29;38(35):7611-7621 pdf
  • Zhao G, Liu F, Oler JA, Meyerand ME, Kalin NH, and Birn RM. Bayesian convolutional neural network based MRI brain extraction on nonhuman primates. NeuroImage. 2018 Jul 15;175:32-44. pdf
  • Block TS, Kushner H, Kalin N, Nelson C, Belanoff J, Schatzberg A. Combined Analysis of Mifepristone for Psychotic Depression: Plasma Levels Associated With Clinical Response. Biological Psychiatry. July 1, 2018; 84:46–54 pdf
  • Kalin NH., M.D. Corticotropin-Releasing Hormone Binding Protein:Stress, Psychopathology, and AntidepressantTreatment Response. American Journal of Psychiatry. 2018 Mar 1;175(3):204-206 pdf
 

2017

  • Alisch RS, Van Hulle C, Chopra P, et al. A multi-dimensional characterization of anxiety in monozygotic twin pairs reveals susceptibility loci in humans. Translational Psychiatry. Dec 2017;7(12):1282. doi:10.1038/s41398-017-0047-9. pdf
  • Block T, Petrides G, Kushner H, Kalin N, Belanoff J, Schatzberg A. Mifepristone Plasma Level and Glucocorticoid Receptor Antagonism Associated With Response in Patients With Psychotic Depression. Journal of Clinical Psychopharmacology. Oct 2017;37(5):505-511. doi:10.1097/JCP.0000000000000744. pdf
  • Bogdan R, Salmeron BJ, Carey CE, et al. Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential. Biological psychiatry. Aug 2017;82(3):165-175. doi:10.1016/j.biopsych.2016.12.030. pdf
  • Kalin NH. Mechanisms Underlying the Early Risk to Develop Anxiety and Depression: A Translational Approach. European neuropsychopharmacology :The journal of the European College of Neuropsychopharmacology. June 2017;27(6):543-553. doi:10.1016/j.euroneuro.2017.03.004. pdf
  • Oler JA, Tromp DPM, Fox AS, et al. Connectivity between the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the non-human primate: neuronal tract tracing and developmental neuroimaging studies. Brain structure & function. Jan 2017;222(1):21-39. doi:10.1007/s00429-016-1198-9. pdf

2016

  • Kalin NH, Fox AS, Kovner R, et al. Overexpressing corticotropin-releasing hormone (CRH) in the primate amygdala increases anxious temperament and alters its neural circuit. Biological psychiatry. Sept 2016;80(5):345-355. doi:10.1016/j.biopsych.2016.01.010. pdf
  • Dantzer R, Kalin NH. The cortisol awakening response at it’s best. Psychoneuroendocrinology. 2016 Jan;63:412-3. pdf  

Selected Past Publications

  • Oler JA, Birn RM, Patriat R, Fox AS, Shelton SE, Burgy CA, Stodola DE, Essex MJ, Davidson RJ, Kalin NH. Evidence for coordinated functional activity within the extended amygdala of nonhuman and human primates. Neuroimage, 61(4): 1059-1066, 2012. pdf
  • Fox AS, Oler JA, Shelton SE, Nanda SA, Davidson RJ, Roseboom PH, Kalin NH. Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates. Proceedings of the National Academy of Sciences, 09(44):18108-13, 2012. pdf
  • Essex MJ, Klein MH, Slattery MJ, Goldsmith HH, Kalin NH. Early risk factors and developmental pathways to chronic inhibition and social anxiety disorder in adolescence. Am J Psychiatry. 2010 Jan; 167(1):40-6. pdf
  • Oler JA, Fox AS, Shleton SE, Rogers J, Dyer TD, Davidson RJ, Shelledy W, Oakes TR, Blangero J, Kalin NH. Amygdalar and hippocampal substrates of anxious temperament differ in their heritability. Nature. 2010 Aug 12; 466(7308):864-8. pdf