As co-investigator on multiple Kalin lab projects, Jonathan’s research combines neuroimaging and molecular studies in pre-clinical models to identify the mechanisms underlying the pathophysiology of anxiety disorders. Jonathan has been involved in studies using fMRI and µPET at the University of Wisconsin for over 15 years, first as a postdoc in the Training Program in Emotion Research (2004-2007), and subsequently as a member of the Kalin laboratory at the HealthEmotions Research Institute in the Department of Psychiatry, where he is studying Anxious Temperament, a nonhuman primate model of the childhood risk to develop anxiety and affective disorders. His translational research has focused on the role of the extended amygdala in emotion and anxiety in human and nonhuman primates. The research program employs intraoperative MRI gene delivery methods and chemogenetic technologies (e.g., DREADDs) to alter the neural circuitry underlying Anxious Temperament with the goal of developing novel treatment strategies for people suffering from severe anxiety and depression. You can follow Jonathan on twitter @jonoler